Pentostatin Other names: Deoxycoformycin

Chemical formula: C₁₁H₁₆N₄O₄  Molecular mass: 268.269 g/mol  PubChem compound: 439693

Active ingredient description

Pentostatin is a potent transition state inhibitor of the enzyme adenosine deaminase. The greatest activity of ADA is found in cells of the lymphoid system with T-cells having higher activity than B-cells and T-cell malignancies higher ADA activity than B-cell malignancies. Pentostatin has been shown to have activity against a variety of lymphoid malignancies, but is most active against indolent cancers with lower ADA concentration, such as hairy cell leukaemia.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L01XX08 Pentostatin L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XX Other antineoplastic agents
Discover more medicines within L01XX08

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
NIPENT Powder for solution for injection/infusion Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 53910-25-1
DrugBank Drug: DB00552
KEGG Drug: D00155
PubChem Compound: 439693
RxNorm Ingredient: 8011
SNOMED-CT Concept: 387154004
Pentostatin (substance)
UNII Identifier: 395575MZO7


Pentostatin is an active ingredient of these brands:

United States (US)

France (FR)

Ireland (IE)

Japan (JP)

Malta (MT)

Spain (ES)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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