Perampanel

Chemical formula: C₂₃H₁₅N₃O  Molecular mass: 349.393 g/mol  PubChem compound: 9924495

Active ingredient description

Perampanel is a first-in-class selective, non-competitive antagonist of the ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor on post-synaptic neurons. Glutamate is the primary excitatory neurotransmitter in the central nervous system and is implicated in a number of neurological disorders caused by neuronal overexcitation. The precise mechanism by which perampanel exerts its antiepileptic effects in humans remains to be fully elucidated.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N03AX22 Perampanel N Nervous system → N03 Antiepileptics → N03A Antiepileptics → N03AX Other antiepileptics
Discover more medicines within N03AX22

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
FYCOMPA Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 380917-97-5
DrugBank Drug: DB08883
KEGG Drug: D08964
PubChem Compound: 9924495
RxNorm Ingredient: 1356552
SNOMED-CT Concept: 703127006
Perampanel (substance)
UNII Identifier: H821664NPK
PERAMPANEL

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