Perphenazine

Chemical formula: C₂₁H₂₆ClN₃OS  Molecular mass: 403.969 g/mol  PubChem compound: 4748

Active ingredient description

Perphenazine is a depressant which blocks dopamine receptors in the central nervous system. It binds to dopamine D1 and D2 receptors and inhibits their activity. Its antiemetic action is mainly due to the inhibition of D2 receptors in the center of the vomiting. Perphenazine also binds to alpha adrenergic receptors and in conjunction with G proteins activate the phosphatidylinositol-calcium system.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N05AB03 Perphenazine N Nervous system → N05 Psycholeptics → N05A Antipsychotics → N05AB Phenothiazines with piperazine structure
Discover more medicines within N05AB03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
PERPHENAN Film coated tablet MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 58-39-9
DrugBank Drug: DB00850
KEGG Drug: D00503
PubChem Compound: 4748
RxNorm Ingredient: 8076
SNOMED-CT Concept: 387229007
Perphenazine (substance)
UNII Identifier: FTA7XXY4EZ
PERPHENAZINE

Medicines

Perphenazine is an active ingredient of these brands:

Finland (FI)

Israel (IL)

Japan (JP)

Mexico (MX)

Spain (ES)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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