Phenazocine

Chemical formula: C₂₂H₂₇NO  Molecular mass: 321.464 g/mol 

Active ingredient description

Phenazocine is an opioid analgesic drug, which is related to pentazocine and has a similar profile of effects. Effects of phenazocine include analgesia and euphoria, also may include dysphoria and hallucinations at high doses, most likely due to action at κ-opioid and σ receptors. Phenazocine appears to be a much stronger analgesic with fewer side effects than pentazocine, probably due to a more favorable μ/κ binding ratio. Phenazocine is a much more potent analgesic than pentazocine and other drugs in the benzomorphan series, most probably due to the presence of an N-phenethyl substitution, which is known to boost μ-opioid activity in many classes of opioid analgesics. Consequently, phenazocine has four times the potency of morphine as an analgesic. Also it does not cause spasm of the sphincter of Oddi, making it more suitable than morphine for the treatment of biliary or pancreatic pain.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N02AD02 Phenazocine N Nervous system → N02 Analgesics → N02A Opioids → N02AD Benzomorphan derivatives
Discover more medicines within N02AD02

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 127-35-5
DrugBank Drug: DB13606
RxNorm Ingredient: 8119
SNOMED-CT Concept: 387326002
Phenazocine (substance)
UNII Identifier: J0ND6N0AQC
PHENAZOCINE

Medicines

Phenazocine is an active ingredient of these brands:

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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