Piroxicam

Chemical formula: C₁₅H₁₃N₃O₄S  Molecular mass: 331.346 g/mol  PubChem compound: 54676228

Therapeutic indications

Piroxicam is indicated for:

Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis

Population group: only adults (18 years old or older)

Piroxicam is indicated for symptomatic relief of osteoarthritis, rheumatoid arthritis, or ankylosing spondylitis.

Due to its safety profile, piroxicam is not a first line option should an NSAID be indicated. The decision to prescribe piroxicam should be based on an assessment of the individual patient’s overall risks.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Osteoarthritis of superficial joints, acute musculoskeletal injuries, periarthritis, epicondylitis, tendinitis, tenosynovitis

Population group: only adults (18 years old or older)

Piroxicam gel is a non-steroidal anti-inflammatory agent indicated for a variety of conditions characterised by pain and inflammation, or stiffness. It is effective in the treatment of osteoarthritis of superficial joints such as the knee, acute musculoskeletal injuries, periarthritis, epicondylitis, tendinitis, and tenosynovitis.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Piroxicam is contraindicated in the following cases:

Lactation

Lactation

Concomitant use with other NSAIDs, acetylsalicylic acid

at least one of
Non steroidal anti-inflammatory drugs (NSAIDS)
Acetylsalicylic acid

Pregnancy

Pregnancy

History of gastro-intestinal ulceration, history of gastro-intestinal bleeding, history of gastro-intestinal perforation

at least one of
Gastrointestinal ulcer
H/O: gastric ulcer
Gastrointestinal hemorrhage
History of gastrointestinal bleed
Gastrointestinal perforation

Patient history of gastrointestinal disorders that predispose to bleeding disorders

at least one of
H/O: gastrointestinal disease
History of inflammatory bowel disease
History of malignant neoplasm of gastrointestinal tract
Diverticulitis

Active peptic ulcer, inflammatory gastrointestinal disorder, gastrointestinal bleeding

at least one of
Peptic ulcer
Inflammatory bowel disease
Gastrointestinal hemorrhage

Anticoagulants

Oral anticoagulants

Severe heart failure

Heart failure

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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Summary of Product Characteristics (SPC) 2021: PIROXICAM Gel
Summary of Product Characteristics (SPC) 2021: PIROXICAM Capsule
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