Chemical formula: C₂₁H₃₃N₃O₅S Molecular mass: 439.569 g/mol PubChem compound: 115163
Pivmecillinam interacts in the following cases:
The bactericidal effect of mecillinam may be hindered by concurrent administration of products with bacteriostatic effect, for instance erythromycin and tetracyclines.
Clearance of methotrexate from the body can be reduced by concurrent use of penicillins.
Simultaneous administration of probenecid reduces the excretion of mecillinam and hence increases the blood level of the antibiotic.
Concurrent treatment with valproic acid, valproate or other medication liberating pivalic acid should be avoided due to increased risk of carnitine depletion.
Pivmecillinam should not be used by patients suffering from porphyria as pivmecillinam has been connected to acute attacks of porphyria.
Pseudomembranous colitis caused by Clostridium difficile may occur. If diarrhoea occurs after use, the possibility of pseudomembranous colitis should be considered, and appropriate precaution should be taken.
A large amount of data on pregnant women (more than 1000 pregnancy outcomes) indicate no malformative nor feto/neonatal toxicity of pivmecillinam/mecillinam. Pivmecillinam can be used during pregnancy if clinically needed.
Pivmecillinam is excreted in human milk, but at therapeutic doses of pivmecillinam no effects on the breast-fed newborns/infants are anticipated. Pivmecillinam can be used during breast-feeding.
There are no clinical studies with Pivmecillinam hydrochloride regarding fertility. A pre-clinical study did not show an effect on fertility in rats.
Pivmecillinam hydrochloride has no or negligible influence on the ability to drive and use machines.
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