Polatuzumab vedotin

Therapeutic indications

Polatuzumab vedotin is indicated for:

Diffuse large B-cell lymphoma (DLBCL)

Population group: only adults (18 years old or older)

In combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHP) it is indicated for the treatment of adult patients with previously untreated diffuse large B-cell lymphoma (DLBCL).

In combination with bendamustine and rituximab it is indicated for the treatment of adult patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) who are not candidates for haematopoietic stem cell transplant.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Polatuzumab vedotin is contraindicated in the following cases:

Fertility

Fertility

Lactation

Lactation

Moderate hepatic impairment, severe hepatic impairment

at least one of
Hepatic failure stage III
Hepatic failure stage IV

Active severe infections

Infectious disease

Live vaccines

Live organism vaccines

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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