Potassium chloride

Chemical formula: KCl  Molecular mass: 74.551 g/mol  PubChem compound: 4873

Interactions

Potassium chloride interacts in the following cases:

NSAIDs

NSAIDs may produce potassium retention by reducing renal synthesis of prostaglandin E and impairing the renin-angiotensin system. Closely monitor potassium in patients on concomitant NSAIDs.

ACE-inhibitors, aliskiren, angiotensin-II receptor anatagonists, potassium-sparing agents, ciclosporin, tacrolimus

Increased risk of severe hyperkalaemia with the following:

  • ACE-inhibitors.
  • Aliskerin.
  • Angiotensin-II receptor anatagonists.
  • Potassium sparing diuretics such as: amiloride, spironolactone and triamterene and aldosterone antagonists.
  • Ciclosporin.
  • Tacrolimus (not topical formulations).

Pregnancy

Potassium chloride should be used during pregnancy only under the supervision of the prescribing physician if considered essential by the physician.

Nursing mothers

Potassium chloride should be used during lactation only under the supervision of the prescribing physician if considered essential by the physician.

Carcinogenesis, mutagenesis and fertility

Carcinogenicity, mutagenicity and fertility studies in animals have not been performed. Potassium is a normal dietary constituent.

Effects on ability to drive and use machines

None known.

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