Pramipexole

Chemical formula: C₁₀H₁₇N₃S  Molecular mass: 211.327 g/mol  PubChem compound: 119570

Active ingredient description

Pramipexole is a dopamine agonist that binds with high selectivity and specificity to the D2 subfamily of dopamine receptors of which it has a preferential affinity to D3 receptors, and has full intrinsic activity. Pramipexole alleviates parkinsonian motor deficits by stimulation of dopamine receptors in the striatum. Animal studies have shown that pramipexole inhibits dopamine synthesis, release, and turnover.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N04BC05 Pramipexole N Nervous system → N04 Anti-parkinson drugs → N04B Dopaminergic agents → N04BC Dopamine agonists
Discover more medicines within N04BC05

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
MIRAPEXIN Tablet / Prolonged-release tablet European Medicines Agency (EU) MPI, EU: SmPC
MIRAPEX Tablet FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 104632-26-0
DrugBank Drug: DB00413
KEGG Drug: D00559
PubChem Compound: 119570
RxNorm Ingredient: 746741
SNOMED-CT Concept: 386852009
Pramipexole (substance)
UNII Identifier: 83619PEU5T
PRAMIPEXOLE

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