Pseudoephedrine

Anticholinergic drugs such as tricyclic antidepressants enhanced effects.

Cardiac glycosides such as digoxin increased risk of dysrhythmias.

Ergot alkaloids (ergotamine & methysergide) increased risk of ergotism.

Pseudoephedrine may increase the possibility of arrhythmias in digitalised patients.

Risk of hypertensive crisis.

Risk of hypertension.

Risk of hypertension.

Caution is advised in patients with prostatic enlargement.

There are limited amount of data on the use of pseudoephedrine in pregnant women. The use of pseudoephedrine during the first trimester of pregnancy has been associated with an increased frequency of gastroschisis (a developmental defect in the abdominal wall with intestinal herniation) and of small intestinal atresia (congenital obstruction of small intestine). Due to the vasoconstrictive properties of pseudoephedrine, it may induce a reduction in uteroplacental circulation.

Pseudoephedrine is not recommended in pregnancy.

Pseudoephedrine has been detected in human milk with a small percentage of the maternal dose potentially administered to the breastfed infant. Irritability and disturbed sleep have been reported in breastfed infants. Pseudoephedrine may suppress lactation.

No adverse effects known.

Adverse effects may include dry mouth, anxiety, restlessness, tremor, insomnia, tachycardia, cardiac arrhythmias, palpitations, hypertension, nausea, vomiting, headache and occasionally urinary retention in males and skin rashes. Hallucinations have been reported rarely, particularly in children.

Immune system disorders:

Hypersensitivity reactions, including cross sensitivity that may occur with other sympathomimetics.

Skin and subcutaneous tissue disorders:

Frequency unknown: Severe skin reactions, including acute generalized exanthematous pustulosis (AGEP).

Gastrointestinal Disorders:

Nausea, vomiting, dry mouth.

Frequency unknown: Ischaemic colitis.

Eye disorders:

Frequency unknown: Ischaemic optic neuropathy.

Nervous system disorders:

Headache, dizziness, tremor.

Frequency unknown: Posterior reversible encephalopathy syndrome (PRES). Reversible cerebral vasoconstriction syndrome (RCVS).

Cardiac disorders:

Tachycardia, palpitations, cardiac arrhythmias.

Renal and urinary disorders:

Urinary retention in males.

Vascular disorders:

Hypertension.

Psychiatric disorders:

Sleep disturbance, insomnia, restlessness, anxiety, hallucinations (particularly in children).