Chemical formula: C₂₄H₃₃N₃O₄ Molecular mass: 427.537 g/mol PubChem compound: 56959
Ranolazine may have some antianginal effects by inhibition of the late sodium current in cardiac cells. This reduces intracellular sodium accumulation and consequently decreases intracellular calcium overload. Ranolazine, via its action to decrease the late sodium current, is considered to reduce these intracellular ionic imbalances during ischaemia. This reduction in cellular calcium overload is expected to improve myocardial relaxation and thereby decrease left ventricular diastolic stiffness.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C01EB18 | Ranolazine | C Cardiovascular system → C01 Cardiac therapy → C01E Other cardiac preparations → C01EB Other cardiac preparations |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| RANEXA Prolonged-release tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Ranolazine is an active ingredient of these brands:
United States (US)Austria (AT)Brazil (BR)Cyprus (CY)Estonia (EE)France (FR)Hong Kong (HK)Ireland (IE)Italy (IT)Lithuania (LT)New Zealand (NZ)Nigeria (NG)Poland (PL)Romania (RO)Singapore (SG)Spain (ES)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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