Ravulizumab

Therapeutic indications

Ravulizumab is indicated for:

Paroxysmal nocturnal haemoglobinuria (PNH)

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Ravulizumab is indicated in the treatment of adult and paediatric patients with a body weight of 10 kg or above with paroxysmal nocturnal haemoglobinuria (PNH):

  • in patients with haemolysis with clinical symptom(s) indicative of high disease activity.
  • in patients who are clinically stable after having been treated with eculizumab for at least the past 6 months.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Atypical haemolytic uremic syndrome (aHUS)

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Ravulizumab is indicated in the treatment of patients with a body weight of 10 kg or above with atypical haemolytic uremic syndrome (aHUS) who are complement inhibitor treatment-naïve or have received eculizumab for at least 3 months and have evidence of response to eculizumab.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Ravulizumab is contraindicated in the following cases:

Lactation

Lactation

Neisseria meningitidis infection

Meningococcal infectious disease

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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