Riociguat

Chemical formula: C₂₀H₁₉FN₈O₂  Molecular mass: 422.416 g/mol  PubChem compound: 11304743

Therapeutic indications

Riociguat is indicated for:

Chronic thromboembolic pulmonary hypertension (CTEPH)

Population group: only adults (18 years old or older)

Riociguat is indicated for the treatment of adult patients with WHO Functional Class (FC) II to III with:

  • inoperable CTEPH,
  • persistent or recurrent CTEPH after surgical treatment, to improve exercise capacity.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Pulmonary arterial hypertension (PAH)

Population group: only adults (18 years old or older)

Riociguat, as monotherapy or in combination with endothelin receptor antagonists, is indicated for the treatment of adult patients with pulmonary arterial hypertension (PAH) with WHO Functional Class (FC) II to III to improve exercise capacity.

Efficacy has been shown in a PAH population including aetiologies of idiopathic or heritable PAH or PAH associated with connective tissue disease.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Riociguat is contraindicated in the following cases:

Pregnancy

Pregnancy

PDE5 inhibitors

PDE5 selective inhibitors

Severe hepatic impairment (Child Pugh C)

Hepatic failure stage IV

Nitrates, nitric oxide

at least one of
Organic nitrates
Nitric oxide (NO)

Hypotension

Hypotension

Pulmonary hypertension associated with idiopathic interstitial pneumonias (PH-IIP)

Pulmonary hypertension due to interstitial lung disease

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