Selumetinib

Chemical formula: C₁₇H₁₅BrClFN₄O₃  Molecular mass: 457.68 g/mol  PubChem compound: 10127622

Active ingredient description

Selumetinib is a selective inhibitor of mitogen activated protein kinase kinases 1 and 2 (MEK ½). Selumetinib blocks MEK activity and the RAF-MEK-ERK pathway. Therefore, MEK inhibition can block the proliferation and survival of tumour cells in which the RAF-MEK-ERK pathway is activated.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L01EE04 L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EE Mitogen-activated protein kinase (MEK) inhibitors
Discover more medicines within L01EE04

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
KOSELUGO Hard capsule European Medicines Agency (EU) MPI, EU: SmPC
KOSELUGO Capsule FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 606143-52-6
DrugBank Drug: DB11689
KEGG Drug: D09666
PubChem Compound: 10127622
RxNorm Ingredient: 2289380
SNOMED-CT Concept: 870689004
Selumetinib (substance)
UNII Identifier: 6UH91I579U
SELUMETINIB

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