Sildenafil Other names: Sildenafil citrate

Chemical formula: C₂₂H₃₀N₆O₄S  Molecular mass: 474.576 g/mol  PubChem compound: 5212

Therapeutic indications

Sildenafil is indicated for:

Erectile dysfunction

Population group: men, only adults (18 years old or older)

Sildenafil is indicated in adult men with erectile dysfunction, which is the inability to achieve or maintain a penile erection sufficient for satisfactory sexual performance. In order for sildenafil to be effective, sexual stimulation is required.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Pulmonary arterial hypertension

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Treatment of paediatric patients aged 1 year to 17 years old with pulmonary arterial hypertension. Efficacy in terms of improvement of exercise capacity or pulmonary haemodynamics has been shown in primary pulmonary hypertension and pulmonary hypertension associated with congenital heart disease.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Pulmonary arterial hypertension classified as WHO functional class II and III

Population group: only adults (18 years old or older)

Sildenafil is indicated for treatment of adult patients with pulmonary arterial hypertension classified as WHO functional class II and III, to improve exercise capacity. Efficacy has been shown in primary pulmonary hypertension and pulmonary hypertension associated with connective tissue disease.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Sildenafil is contraindicated in the following cases:

Nitric oxide, nitrates

at least one of
Nitric oxide (NO)
Organic nitrates

Guanylate cyclase stimulators

Guanylate cyclase stimulators

Ketoconazole, itraconazole, ritonavir

at least one of
Ketoconazole
Itraconazole
Ritonavir

Non-arteritic anterior ischaemic optic neuropathy (NAION)

Anterior ischaemic optic neuropathy

Severe hepatic impairment

Hepatic failure stage IV

Recent history of myocardial infarction

at least one of
Myocardial infarction
Past history of myocardial infarction

Severe hypotension (blood pressure <90/50 mmHg)

Hypotension

Ritonavir

Ritonavir

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