Chemical formula: NaClO₄ Molecular mass: 122.44 g/mol
Perchlorate competitively inhibits the thyroid’s iodine uptake mechanism, iodination and affects iodisation by flushing the thyroid of iodide that is accumulating but has not yet been incorporated into a thyroglobulin molecule. Re-utilisation of iodide released outside the thyroid during deiodination of thyroid hormone is also inhibited. The antithyroid effect is based on the occurrence of iodine depletion.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| H03BC | Perchlorates | H Systemic hormonal preparations, excl. Sex hormones and insulins → H03 Thyroid therapy → H03B Antithyroid preparations |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| IRENAT Oral drops | Base de données publique des médicaments (FR) | MPI, EU: SmPC |
Sodium perchlorate is an active ingredient of these brands:
Estonia (EE)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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