Strontium ranelate

Chemical formula: C₁₂H₆N₂O₈SSr₂  Molecular mass: 513.49 g/mol  PubChem compound: 6918182

Therapeutic indications

Strontium ranelate is indicated for:

Severe osteoporosis

Population group: only adults (18 years old or older)

Treatment of severe osteoporosis:

  • in postmenopausal women;
  • in adult men

at high risk of fracture, for whom treatment with other medicinal products approved for the treatment of osteoporosis is not possible due to, for example, contraindications or intolerance. In postmenopausal women, strontium ranelate reduces the risk of vertebral and hip fractures.

The decision to prescribe strontium ranelate should be based on an assessment of the individual patient’s overall risks.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Strontium ranelate is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Venous thromboembolic events (VTE)

at least one of
Thromboembolism of vein
History of venous thromboembolic disease
Deep venous thrombosis
History of deep vein thrombosis
Pulmonary embolism

Uncontrolled hypertension

Hypertension

Ischaemic heart disease, peripheral arterial disease, cerebrovascular disease

at least one of
Ischemic heart disease
Peripheral arterial vascular disease
History of peripheral vascular disease
Cerebrovascular disease
H/O: cerebrovascular disease

Immobilisation

at least one of
Musculoskeletal immobility
† Immobile

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Factors such as age, gender, and health history are evaluated to create a personalized medication regimen.

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Summary of Product Characteristics (SPC) 2020: STRONTIUM RANELATE ARISTO Granules
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