Chemical formula: C₁₀H₁₀N₄O₂S Molecular mass: 250.277 g/mol PubChem compound: 5215
Sulfadiazine is a structural analogue and competitive antagonist of p-aminobenzoic acid preventing bacterial utilisation of PABA in the synthesis of folic acid.
Sulfadiazine is rapidly absorbed from the gastrointestinal tract after oral dosage. Peak blood concentrations are reached within three to six hours, and about 50% is bound to plasma protein.
The serum half-life is about 17 hours, and about 80% of the dose is excreted in the urine within two to three days.
There are no pre-clinical data of relevance to the prescriber that are additional to those included in other sections.
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