Tasonermin

Therapeutic indications

Tasonermin is indicated for:

Soft tissue sarcoma of the limbs

Population group: only adults (18 years old or older)

Tasonermin is indicated in adults as an adjunct to surgery for subsequent removal of the tumour so as to prevent or delay amputation, or in the palliative situation, for irresectable soft tissue sarcoma of the limbs, used in combination with melphalan via mild hyperthermic isolated limb perfusion (ILP).

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Tasonermin is contraindicated in the following cases:

Pregnancy

Pregnancy

Lactation

Lactation

Cardiovascular disease, pulmonary embolism

at least one of
Cardiovascular disorder
Pulmonary embolism

Severe pulmonary dysfunction

Lung disorder

Peptic ulcer

Peptic ulcer

Severe ascites

Ascites

Leucocytes <2.5 x 10⁹/l, haemoglobin <9 g/dl, platelets <60 x 10⁹/l, bleeding

at least one of
Decreased blood leukocyte number
† Haemoglobin very low
Platelet count below reference range
Bleeding

Significant renal dysfunction

at least one of


Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Significant hepatic dysfunction

Hepatic failure stage IV

Hypercalcaemia

Hypercalcemia

Anthracyclines

Anthracyclines and related substances

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