Chemical formula: C₁₀H₁₄N₂O₅ Molecular mass: 242.229 g/mol PubChem compound: 159269
Telbivudine is a synthetic thymidine nucleoside analogue with activity against HBV DNA polymerase. It is efficiently phosphorylated by cellular kinases to the active triphosphate form. Incorporation of telbivudine-5'-triphosphate into viral DNA causes DNA chain termination, resulting in inhibition of HBV replication.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| J05AF11 | Telbivudine | J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AF Nucleoside and nucleotide reverse transcriptase inhibitors |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| SEBIVO Film-coated tablet | European Medicines Agency (EU) | MPI, EU: SmPC |
Telbivudine is an active ingredient of these brands:
Estonia (EE)Hong Kong (HK)Lithuania (LT)Poland (PL)Romania (RO)Singapore (SG)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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