Tobramycin

Chemical formula: C₁₈H₃₇N₅O₉  Molecular mass: 467.515 g/mol  PubChem compound: 36294

Active ingredient description

Tobramycin is an aminoglycoside antibiotic produced by Streptomyces tenebrarius. It acts primarily by disrupting protein synthesis leading to altered cell membrane permeability, progressive disruption of the cell envelope and eventual cell death. It is bactericidal at concentrations equal to or slightly greater than inhibitory concentrations.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
J01GB01 Tobramycin J Antiinfectives for systemic use → J01 Antibacterials for systemic use → J01G Aminoglycoside antibacterials → J01GB Other aminoglycosides
Discover more medicines within J01GB01
S01AA12 Tobramycin S Sensory organs → S01 Ophthalmologicals → S01A Antiinfectives → S01AA Antibiotics
Discover more medicines within S01AA12

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
TOBI Podhaler Inhalation powder, hard capsule European Medicines Agency (EU) MPI, EU: SmPC
TOBRAMYCIN Solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 32986-56-4
CAS Substance: 49842-07-1
DrugBank Drug: DB00684
KEGG Drug: D00063
PubChem Compound: 36294
RxNorm Ingredient: 10627
SNOMED-CT Concept: 373548001
Tobramycin (substance)
UNII Identifier: VZ8RRZ51VK
TOBRAMYCIN

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