Trametinib

Chemical formula: C₂₆H₂₃FIN₅O₄  Molecular mass: 615.395 g/mol  PubChem compound: 11707110

Active ingredient description

Trametinib is a reversible, highly selective, allosteric inhibitor of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2 activation and kinase activity. In melanoma and other cancers, this pathway is often activated by mutated forms of BRAF which activates MEK. Trametinib inhibits activation of MEK by BRAF and inhibits MEK kinase activity.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L01EE01 L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EE Mitogen-activated protein kinase (MEK) inhibitors
Discover more medicines within L01EE01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
MEKINIST Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC
SPEXOTRAS Powder for oral solution European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 871700-17-3
DrugBank Drug: DB08911
KEGG Drug: D10175
PubChem Compound: 11707110
RxNorm Ingredient: 1425099
SNOMED-CT Concept: 708711009
Trametinib (substance)
UNII Identifier: 33E86K87QN
TRAMETINIB

Medicines

Trametinib is an active ingredient of these brands:

United States (US)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

Australia (AU)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

Austria (AT)

Brazil (BR)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

Canada (CA)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

Croatia (HR)

Cyprus (CY)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

Ecuador (EC)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

Estonia (EE)

Finland (FI)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

France (FR)

Hong Kong (HK)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

Ireland (IE)

Israel (IL)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

Italy (IT)

Japan (JP)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

Lithuania (LT)

Netherlands (NL)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

New Zealand (NZ)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

Poland (PL)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

Romania (RO)

Singapore (SG)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

South Africa (ZA)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

Spain (ES)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

Turkey (TR)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

United Kingdom (UK)

  • MEKINIST as TRAMETINIB DIMETHYL SULFOXIDE

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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