Treosulfan

Chemical formula: C₆H₁₄O₈S₂ Molecular mass: 278.29 g/mol PubChem compound: 9882105

Therapeutic indications

Treosulfan is indicated for:

Allogeneic haematopoietic stem cell transplantation (alloHSCT)

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old) , adults (18 years old or older)

Treosulfan in combination with fludarabine is indicated as part of conditioning treatment prior to allogeneic haematopoietic stem cell transplantation (alloHSCT) in adult patients and in paediatric patients older than one month with malignant and non-malignant diseases.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

For adults with malignant disease 10 g/m² once daily for 3 consecutive days and for adults with non-malignant disesae 14 g/m² once daily for 3 consecutive days

10-14 g/m² once daily for 3 consecutive days

Contraindications

Treosulfan is contraindicated in the following cases:

Pregnancy

Active non-controlled infectious disease

Infectious disease

Fanconi anaemia and other DNA breakage repair disorders

at least one of

Fanconi pancytopenia syndrome
Ataxia-telangiectasia syndrome
Bloom syndrome
Cockayne syndrome
Hutchinson-Gilford syndrome
Rothmund-Thomson syndrome
Werner syndrome
Xeroderma pigmentosum

Severe cardiac impairment

Cardiac failure

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Severe liver impairment

Hepatic failure stage IV

Severe lung impairment

Respiratory failure

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