Chemical formula: C₂₀H₂₈O₂ Molecular mass: 300.442 g/mol PubChem compound: 5538
Tretinoin decreases cohesiveness of follicular epithelial cells resulting in decreased microcomedone formation. Additionally, tretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells, causing extrusion of the comedones.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
|D Dermatologicals → D10 Anti-acne preparations → D10A Anti-acne preparations for topical use → D10AD Retinoids for topical use in acne
|L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XF Retinoids for cancer treatment
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
|RETIN-A Cream / Gel
|FDA, National Drug Code (US)
|MPI, US: SPL/Old
|Medicines & Healthcare Products Regulatory Agency (GB)
|MPI, EU: SmPC
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