Tretinoin Other names: ATRA Retinoic Acid All-trans retinoic acid

Chemical formula: C₂₀H₂₈O₂ Molecular mass: 300.442 g/mol PubChem compound: 5538

Active ingredient description

Tretinoin decreases cohesiveness of follicular epithelial cells resulting in decreased microcomedone formation. Additionally, tretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells, causing extrusion of the comedones.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code	Group title	Classification
D10AD01	Tretinoin	D Dermatologicals → D10 Anti-acne preparations → D10A Anti-acne preparations for topical use → D10AD Retinoids for topical use in acne
Discover more medicines within D10AD01
L01XF01	Tretinoin	L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XF Retinoids for cancer treatment
Discover more medicines within L01XF01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title	Information Source	Document Type
RETIN-A Cream / Gel	FDA, National Drug Code (US)	MPI, US: SPL/Old
TRETINOIN Capsule	Medicines & Healthcare Products Regulatory Agency (GB)	MPI, EU: SmPC

Medicines

Tretinoin is an active ingredient of these brands:

United States (US)

ALTRENO
ATRALIN
AVITA
REFISSA
RENOVA
RETIN-A
(combination) TRI-LUMA
(combination) VELTIN
(combination) ZIANA

Austria (AT)

VESANOID
(combination) ACNATAC

Brazil (BR)

VESANOID
VITACID
VITANOL-A
(combination) HORMOSKIN
(combination) OSKIN
(combination) SUAVICID
(combination) TRI-LUMA
(combination) TRINULOX
(combination) VITACID ACNE
(combination) VITACID PLUS

Canada (CA)

Croatia (HR)

VESANOID

Cyprus (CY)

(combination) ACNATAC

Ecuador (EC)

BETARRETIN
(combination) BETARRETIN H
(combination) TRI-LUMA

Israel (IL)

Japan (JP)

OLCENON as TRETINOIN TOCOFERIL
VESANOID

Lithuania (LT)

(combination) TRECLINAC

Malta (MT)

KETREL
VESANOID
(combination) TRECLIN

Mexico (MX)

Netherlands (NL)

VESANOID
(combination) TRECLINAC

New Zealand (NZ)

Poland (PL)

VESANOID
(combination) ACNATAC
(combination) AKNEMYCIN PLUS
(combination) ATREDERM

Romania (RO)

VESANOID
(combination) ACNATAC

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

LOCACID
(combination) ERYLIK

Turkey (TR)

ACNELYSE
AKNEVIT
VESANOID
(combination) CLINDATRE
(combination) ERITRETIN

United Kingdom (UK)

(combination) AKNEMYCIN PLUS
(combination) TRECLIN

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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