Tretinoin Other names: ATRA Retinoic Acid All-trans retinoic acid

Chemical formula: C₂₀H₂₈O₂  Molecular mass: 300.442 g/mol  PubChem compound: 5538

Active ingredient description

Tretinoin decreases cohesiveness of follicular epithelial cells resulting in decreased microcomedone formation. Additionally, tretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells, causing extrusion of the comedones.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
D10AD01 Tretinoin D Dermatologicals → D10 Anti-acne preparations → D10A Anti-acne preparations for topical use → D10AD Retinoids for topical use in acne
Discover more medicines within D10AD01
L01XF01 Tretinoin L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XF Retinoids for cancer treatment
Discover more medicines within L01XF01

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
RETIN-A Cream / Gel FDA, National Drug Code (US) MPI, US: SPL/Old
TRETINOIN Capsule Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 302-79-4
DrugBank Drug: DB00755
KEGG Drug: D00094
PubChem Compound: 5538
RxNorm Ingredient: 10753
SNOMED-CT Concept: 387305002
Tretinoin (substance)
UNII Identifier: 5688UTC01R

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