Trientine Other names: Triethylenetetramine

Chemical formula: C₆H₁₈N₄  Molecular mass: 146.234 g/mol  PubChem compound: 5565

Active ingredient description

Trientine is a copper-chelating agent whose principal mechanism of action is to eliminate absorbed copper from the body by forming a stable complex that is then eliminated through urinary excretion. Trientine may also chelate copper in the intestinal tract and so inhibit copper absorption.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A16AX12 A Alimentary tract and metabolism → A16 Other alimentary tract and metabolism products → A16A Other alimentary tract and metabolism products → A16AX Various alimentary tract and metabolism products
Discover more medicines within A16AX12

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
CUPRIOR Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 112-24-3
CAS Substance: 38260-01-4
DrugBank Drug: DB06824
PubChem Compound: 5565
RxNorm Ingredient: 10798
SNOMED-CT Concept: 373456001
Trientine (substance)
UNII Identifier: SJ76Y07H5F
TRIENTINE

Medicines

Trientine is an active ingredient of these brands:

United States (US)

  • SYPRINE as TRIENTINE HYDROCHLORIDE

Austria (AT)

  • CUFENCE as TRIENTINE HYDROCHLORIDE
  • CUPRIOR as TRIENTINE TETRAHYDROCHLORIDE

Brazil (BR)

Croatia (HR)

  • CUFENCE as TRIENTINE HYDROCHLORIDE
  • CUPRIOR as TRIENTINE TETRAHYDROCHLORIDE

Estonia (EE)

  • CUFENCE as TRIENTINE HYDROCHLORIDE
  • CUPRIOR as TRIENTINE TETRAHYDROCHLORIDE

Finland (FI)

  • CUPRIOR as TRIENTINE TETRAHYDROCHLORIDE

France (FR)

  • CUFENCE as TRIENTINE HYDROCHLORIDE
  • CUPRIOR as TRIENTINE TETRAHYDROCHLORIDE

Ireland (IE)

  • CUFENCE as TRIENTINE HYDROCHLORIDE
  • CUPRIOR as TRIENTINE TETRAHYDROCHLORIDE

Japan (JP)

Lithuania (LT)

  • CUFENCE as TRIENTINE HYDROCHLORIDE
  • CUPRIOR as TRIENTINE TETRAHYDROCHLORIDE

Netherlands (NL)

  • CUPRIOR as TRIENTINE TETRAHYDROCHLORIDE

New Zealand (NZ)

  • CUPRIOR as TRIENTINE TETRAHYDROCHLORIDE

Poland (PL)

  • CUFENCE as TRIENTINE HYDROCHLORIDE
  • CUPRIOR as TRIENTINE TETRAHYDROCHLORIDE

Romania (RO)

  • CUPRIOR as TRIENTINE TETRAHYDROCHLORIDE

Turkey (TR)

  • NOVILS as TRIENTINE HYDROCHLORIDE
  • SIPRYNE as TRIENTINE HYDROCHLORIDE
  • TRENDIN as TRIENTINE HYDROCHLORIDE
  • WILENTIN as TRIENTINE HYDROCHLORIDE

United Kingdom (UK)

  • CUFENCE as TRIENTINE HYDROCHLORIDE
  • CUPRIOR as TRIENTINE TETRAHYDROCHLORIDE

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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