Trimethobenzamide

Chemical formula: C₂₁H₂₈N₂O₅  Molecular mass: 388.457 g/mol  PubChem compound: 5577

Active ingredient description

Trimethobenzamide is used for the treatment of postoperative nausea and vomiting and for nausea associated with gastroenteritis. The mechanism of action of trimethobenzamide as determined in animals is obscure, but may involve the chemoreceptor trigger zone (CTZ), an area in the medulla oblongata through which emetic impulses are conveyed to the vomiting center; direct impulses to the vomiting center apparently are not similarly inhibited.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
R06AA10 R Respiratory system → R06 Antihistamines for systemic use → R06A Antihistamines for systemic use → R06AA Aminoalkyl ethers
Discover more medicines within R06AA10

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
TIGAN Capsule FDA, National Drug Code (US) MPI, US: SPL/PLR
TIGAN Solution for injection FDA, National Drug Code (US) MPI, US: SPL/Old

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 138-56-7
DrugBank Drug: DB00662
KEGG Drug: D08643
PubChem Compound: 5577
RxNorm Ingredient: 38685
SNOMED-CT Concept: 372657005
Trimethobenzamide (substance)
UNII Identifier: W2X096QY97
TRIMETHOBENZAMIDE

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