Vandetanib

Chemical formula: C₂₂H₂₄BrFN₄O₂  Molecular mass: 475.354 g/mol  PubChem compound: 3081361

Therapeutic indications

Vandetanib is indicated for:

Medullary thyroid cancer (MTC)

Population group: only adults (18 years old or older)

Vandetanib is indicated for the treatment of aggressive and symptomatic medullary thyroid cancer (MTC) in patients with unresectable locally advanced or metastatic disease.

Vandetanib is indicated in adults, children and adolescents aged 5 years and older.

For patients in whom Rearranged during Transfection (RET) mutation is not known or is negative, a possible lower benefit should be taken into account before individual treatment decision.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Medullary thyroid cancer (MTC)

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Vandetanib is indicated for the treatment of aggressive and symptomatic medullary thyroid cancer (MTC) in patients with unresectable locally advanced or metastatic disease.

Vandetanib is indicated in adults, children and adolescents aged 5 years and older.

For patients in whom Rearranged during Transfection (RET) mutation is not known or is negative, a possible lower benefit should be taken into account before individual treatment decision.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Vandetanib is contraindicated in the following cases:

Congenital long QTc syndrome, prolonged QT interval over 480 msec, Torsades de pointes

at least one of
Congenital long QT syndrome
Prolonged QT interval
Torsades de pointes
Drugs prolonging QT interval

Lactatiob

Lactation

Medicinal products known to also prolong the QTc interval

Drugs prolonging QT interval

Medicinal products known to induce Torsades de pointes

Drugs inducing Torsade de Pointes

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