Varenicline

Chemical formula: C₁₃H₁₃N₃  Molecular mass: 211.268 g/mol  PubChem compound: 5310966

Active ingredient description

Varenicline binds with high affinity and selectivity at the α4β2 neuronal nicotinic acetylcholine receptors, where it acts as a partial agonist – a compound that has both agonist activity, with lower intrinsic efficacy than nicotine, and antagonist activities in the presence of nicotine.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
N07BA03 Varenicline N Nervous system → N07 Other nervous system drugs → N07B Drugs used in addictive disorders → N07BA Drugs used in nicotine dependence
Discover more medicines within N07BA03
S01XA28 S Sensory organs → S01 Ophthalmologicals → S01X Other ophthalmologicals → S01XA Other ophthalmologicals
Discover more medicines within S01XA28

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
CHAMPIX Film-coated tablets Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 249296-44-4
CAS Substance: 375815-87-5
DrugBank Drug: DB01273
KEGG Drug: D08669
PubChem Compound: 5310966
RxNorm Ingredient: 591622
SNOMED-CT Concept: 421772003
Varenicline (substance)
UNII Identifier: W6HS99O8ZO
VARENICLINE

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