Verapamil Other names: Verapamil hydrochloride

Chemical formula: C₂₇H₃₈N₂O₄  Molecular mass: 454.602 g/mol  PubChem compound: 2520

Therapeutic indications

Verapamil is indicated for:

Mild to moderate hypertension

Population group: only adults (18 years old or older)

The management of mild to moderate hypertension and renal hypertension, used alone or in combination with other antihypertensive therapy.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Angina pectoris

Population group: only adults (18 years old or older)

For the management and prophylaxis of angina pectoris.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Paroxysmal supraventricular tachycardia

Population group: only newborns (0 - 40 days old)

The treatment and prophylaxis of paroxysmal supraventricular tachycardia and the reduction of the ventricular rate in atrial fibrillation/flutter. Verapamil should not be used for atrial fibrillation/flutter in patients with Wolff-Parkinson-White syndrome.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Paroxysmal supraventricular tachycardia

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)

The treatment and prophylaxis of paroxysmal supraventricular tachycardia and the reduction of the ventricular rate in atrial fibrillation/flutter. Verapamil should not be used for atrial fibrillation/flutter in patients with Wolff-Parkinson-White syndrome.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prevention of angina pectoris

Population group: only adults (18 years old or older)

For the management and prophylaxis of angina pectoris.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Paroxysmal supraventricular tachycardia

Population group: only adults (18 years old or older)

The treatment and prophylaxis of paroxysmal supraventricular tachycardia and the reduction of the ventricular rate in atrial fibrillation/flutter. Verapamil should not be used for atrial fibrillation/flutter in patients with Wolff-Parkinson-White syndrome.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prevention of paroxysmal supraventricular tachycardia

Population group: only newborns (0 - 40 days old)

The treatment and prophylaxis of paroxysmal supraventricular tachycardia and the reduction of the ventricular rate in atrial fibrillation/flutter. Verapamil should not be used for atrial fibrillation/flutter in patients with Wolff-Parkinson-White syndrome.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prevention of paroxysmal supraventricular tachycardia

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)

The treatment and prophylaxis of paroxysmal supraventricular tachycardia and the reduction of the ventricular rate in atrial fibrillation/flutter. Verapamil should not be used for atrial fibrillation/flutter in patients with Wolff-Parkinson-White syndrome.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Verapamil is contraindicated in the following cases:

Cardiogenic shock

Cardiogenic shock

Acute myocardial infarction

Acute myocardial infarction

2nd degree AV block

Second degree atrioventricular block

3rd degree AV block

Complete atrioventricular block

Sick sinus syndrome

Sick sinus syndrome

Sinoatrial block

Sinoatrial block

Uncompensated heart failure

Decompensated cardiac failure

Hypotension (less than 90 mmHg systolic)

Hypotension

Atrial flutter

Atrial flutter

Atrial fibrillation

Atrial fibrillation

Bradycardia (less than 50 beats/minute)

Bradycardia

Wolff-Parkinson-White syndrome

Ventricular pre-excitation with arrhythmia

Lown-Ganong-Levine syndrome

Lown-Ganong-Levine syndrome

Ivabradine

Ivabradine

Grapefruit

Grapefruit

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