Vericiguat

Chemical formula: C₁₉H₁₆F₂N₈O₂  Molecular mass: 426.388 g/mol 

Active ingredient description

Vericiguat is a stimulator of soluble guanylate cyclase (sGC). Heart failure is associated with impaired synthesis of nitric oxide (NO) and decreased activity of its receptor, sGC. The pharmacodynamic effects of vericiguat are consistent with the mode of action of a sGC stimulator resulting in smooth muscle relaxation and vasodilation.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C01DX22 C Cardiovascular system → C01 Cardiac therapy → C01D Vasodilators used in cardiac diseases → C01DX Other vasodilators used in cardiac diseases
Discover more medicines within C01DX22

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
VERQUVO Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 1350653-20-1
DrugBank Drug: DB15456
KEGG Drug: D11051
RxNorm Ingredient: 2475830
UNII Identifier: LV66ADM269
VERICIGUAT

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