Folic acid Other names: Folacin Vitamin B9 Vitamin Bc

Chemical formula: C₁₉H₁₉N₇O₆  Molecular mass: 441.398 g/mol  PubChem compound: 6037

Therapeutic indications

Folic acid is indicated for:

Folate-deficient megaloblastic anaemia

Population group: only adults (18 years old or older)

For the treatment of folate-deficient megaloblastic anaemia due to malnutrition, malabsorption syndromes (such as coeliac disease or sprue) and increased utilisation as in pregnancy. It should not be used alone in undiagnosed megaloblastic anaemia including in infancy, pernicious anaemia or macrocytic anaemia of unknown aetiology, unless administered with adequate amounts of hydroxocobalamin.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prophylaxis of folate deficiency in chronic haemolytic states or in renal dialysis

Population group: only adults (18 years old or older)

For the prophylaxis against folate deficiency in chronic haemolytic states or in renal dialysis.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prophylaxis of drug induced folate deficiency

Population group: only adults (18 years old or older)

For the prophylaxis of drug induced folate deficiency e.g. caused by administration of phenytoin, phenobarbital and primidone.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prevention of neural tube defects in pregnancy

Population group: women, only adults (18 - 65 years old)

For the prevention of neural tube defects for woman planning a pregnancy and known to be at risk.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Megaloblastic anemia due to folate deficiency in pregnancy and lactation

Population group: women, only adults (18 - 65 years old)

Megaloblastic anemia due to folate deficiency in pregnancy and lactation

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Folate-deficient megaloblastic anaemia

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

For the treatment of folate-deficient megaloblastic anaemia due to malnutrition, malabsorption syndromes (such as coeliac disease or sprue) and increased utilisation as in pregnancy. It should not be used alone in undiagnosed megaloblastic anaemia including in infancy, pernicious anaemia or macrocytic anaemia of unknown aetiology, unless administered with adequate amounts of hydroxocobalamin.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prophylaxis of folate deficiency in chronic haemolytic states or in renal dialysis

Population group: only adolescents (12 years - 18 years old)

Preventive procedure and additionally Megaloblastic anemia due to folate deficiency and additionally at least one of
Chronic hemolytic anemia
Renal dialysis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prophylaxis of folate deficiency in chronic haemolytic states

Population group: only children (1 year - 12 years old)

Preventive procedure and additionally Megaloblastic anemia due to folate deficiency and additionally Chronic hemolytic anemia

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Prophylaxis of folate deficiency in renal dialysis

Population group: only children (1 year - 12 years old)

Preventive procedure and additionally Megaloblastic anemia due to folate deficiency and additionally Renal dialysis

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Folic acid is contraindicated in the following cases:

Malignant disease

Malignant neoplasms

Addisonian pernicious anaemia

Pernicious anemia

Untreated cobalamin deficiency

Vitamin B12 deficiency

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