Chemical formula: C₁₉H₁₆O₄  Molecular mass: 308.328 g/mol  PubChem compound: 54678486

Active ingredient description

Warfarin is a synthetic 4-Hydroxycoumarin derivative which acts by preventing the formation of active procoagulation factors II, VII, IX and X in the liver by inhibiting the vitamin K – mediated gammacarboxylation of precursor proteins. Full therapeutic activity is not achieved until circulating coagulation factors have been removed by normal catabolism. This occurs at different rates for each factor, with factor VII having the shortest half-life. Warfarin has no direct thrombolytic effect, though it may limit the extension of existing thrombi.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
B01AA03 Warfarin B Blood and blood forming organs → B01 Antithrombotic agents → B01A Antithrombotic agents → B01AA Vitamin K antagonists
Discover more medicines within B01AA03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
WARFARIN Tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
COUMADIN Tablet FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 129-06-6
CAS Substance: 81-81-2
DrugBank Drug: DB00682
PubChem Compound: 54678486
RxNorm Ingredient: 11289
SNOMED-CT Concept: 372756006
Warfarin (substance)
UNII Identifier: 5Q7ZVV76EI


Warfarin is an active ingredient of these brands:

United States (US)

Australia (AU)

Brazil (BR)

Croatia (HR)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Germany (DE)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Lithuania (LT)

Mexico (MX)

New Zealand (NZ)

Poland (PL)

Singapore (SG)

South Africa (ZA)


Spain (ES)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.