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ATC Group: A06AB Contact laxatives

Anatomical Therapeutic Chemical Classification System

Hierarchical Position

Level
Code
Title
1
A
Alimentary tract and metabolism
2
A06
Laxatives
3
A06A
Laxatives
4
A06AB
Contact laxatives

Contents

Code
Title
A06AB01
Oxyphenisatine
A06AB02
Bisacodyl
A06AB03
Dantron
A06AB04
Phenolphthalein
A06AB05
Castor oil
A06AB06
Senna glycosides
A06AB07
Cascara
A06AB08
Sodium picosulfate
A06AB09
Bisoxatin
A06AB20
Contact laxatives in combination
A06AB30
Contact laxatives in combination with belladonna alkaloids
A06AB52
Bisacodyl, combinations
A06AB53
Dantron, combinations
A06AB56
Senna glycosides, combinations
A06AB57
Cascara, combinations
A06AB58
Sodium picosulfate, combinations

Active Ingredients

Chemical substance
Description
Bisacodyl

Bisacodyl is a locally acting laxative from the diphenylmethane derivatives group having a dual action. As a contact laxative, for which also antiresorptive hydragogue effects have been described, bisacodyl stimulates after hydrolysis in the large intestine, the mucosa of both the large intestine and of the rectum. Stimulation of the mucosa of the large intestine results in colonic peristalsis with promotion of accumulation of water, and consequently electrolytes, in the colonic lumen. This results in a stimulation of defecation, reduction of transit time and softening of the stool. Stimulation of the rectum causes increased motility and a feeling of rectal fullness. The rectal effect may help to restore the “call to stool” although its clinical relevance remains to be established.

Castor oil

Castor oil is a vegetable oil pressed from the seeds of the castor bean, Ricinus communis. Castor oil is used medicinally as a laxative and as an excipient.

Danthron

Danthron, a natural product, was originally extracted from the roots and rhizome of Polygonaceae plant. Danthron is a reddish, synthetic anthraquinone derivative. Danthron has been widely used as a laxative.

Sennosides

The sugar moiety of the sennosides is removed by bacteria in the large intestine releasing the active anthrone fraction. This stimulates peristalsis via the submucosal and myenteric nerve plexuses.

Sodium picosulfate

Sodium picosulfate is a locally acting laxative from the triarylmethane group, which after bacterial cleavage in the colon, has a dual-action with stimulation of the mucosa of both the large intestine and of the rectum.

Monographs

Monograph
Type
Country
DULCOLAX Gastro-resistant tablets
MPI, EU: SmPC
UK
SENOKOT Syrup
MPI, EU: SmPC
UK