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ATC Group: A06AX Other laxatives

Anatomical Therapeutic Chemical Classification System

Hierarchical Position

Level
Code
Title
1
A
Alimentary tract and metabolism
2
A06
Laxatives
3
A06A
Laxatives
4
A06AX
Other laxatives

Contents

Code
Title
A06AX01
Glycerol
A06AX02
Carbon dioxide producing drugs
A06AX03
Lubiprostone
A06AX04
Linaclotide
A06AX05
Prucalopride
A06AX06
Tegaserod
A06AX07
Plecanatide
A06AX08
Tenapanor

Active Ingredients

Chemical substance
Description
Glycerol

Glycerol has uses as a hyperosmotic, osmotic diuretic, and ophthalmic agent. It may be used as an eye drop in the treatment of glaucoma to reduce intraocular pressure, as a solution or suppository for short-term treatment of constipation, to evacuate the bowel prior to a colonoscopy, and in some ocular surgeries. It may be given intravenously to reduce pressure inside the brain and used externally on the skin as a moisturizer.

Linaclotide

Linaclotide is a Guanylate Cyclase-C receptor agonist (GCCA) with visceral analgesic and secretory activities. Through its action at GC-C, linaclotide has been shown to reduce visceral pain and increase GI transit in animal models and increase colonic transit in humans.

Lubiprostone

Lubiprostone is a locally acting chloride channel activator that enhances a chloride-rich intestinal fluid secretion without altering sodium and potassium concentrations in the serum. By increasing intestinal fluid secretion, lubiprostone increases motility in the intestine, thereby facilitating the passage of stool and alleviating symptoms associated with chronic idiopathic constipation (CIC).

Plecanatide

Plecanatide is a structural analog of human uroguanylin, and similarly to uroguanylin, plecanatide functions as a guanylate cyclase-C (GC-C) agonist. Both plecanatide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium. Activation of GC-C results in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP).

Prucalopride

Prucalopride is a dihydrobenzofurancarboxamide with gastrointestinal prokinetic activities. Prucalopride is a selective, high affinity serotonin (5-HT4) receptor agonist, which is likely to explain its prokinetic effects.

Tegaserod

Tegaserod is an agonist of serotonin type-4 (5-HT4) receptors that stimulates the peristaltic reflex and intestinal secretion, inhibits visceral sensitivity, enhances basal motor activity, and normalizes impaired motility throughout the gastrointestinal tract.

Monographs

Monograph
Type
Country
AMITIZA Capsule
MPI, US: SPL/PLR
US
CONSTELLA Hard capsule
MPI, EU: SmPC
GLYCERIN BP Liquid
MPI, EU: SmPC
UK
GLYCERIN Suppository
MPI, EU: SmPC
UK
IBSRELA Tablet
MPI, US: SPL/PLR
US
RESOLOR Film-coated tablet
MPI, EU: SmPC