Lubiprostone

Chemical formula: C₂₀H₃₂F₂O₅  Molecular mass: 390.468 g/mol  PubChem compound: 157920

Active ingredient description

Lubiprostone is a locally acting chloride channel activator that enhances a chloride-rich intestinal fluid secretion without altering sodium and potassium concentrations in the serum. By increasing intestinal fluid secretion, lubiprostone increases motility in the intestine, thereby facilitating the passage of stool and alleviating symptoms associated with chronic idiopathic constipation (CIC).

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A06AX03 Lubiprostone A Alimentary tract and metabolism → A06 Laxatives → A06A Laxatives → A06AX Other laxatives
Discover more medicines within A06AX03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
AMITIZA Capsule FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 333963-40-9
DrugBank Drug: DB01046
KEGG Drug: D04790
PubChem Compound: 157920
RxNorm Ingredient: 623033
SNOMED-CT Concept: 421856003
Lubiprostone (substance)
UNII Identifier: 7662KG2R6K
LUBIPROSTONE

Medicines

Lubiprostone is an active ingredient of these brands:

United States (US)

Brazil (BR)

Ecuador (EC)

Japan (JP)

Singapore (SG)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.