ATC Group: C09XX Other agents acting on the renin-angiotensin system

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of C09XX in the ATC hierarchy

Level Code Title
1 C Cardiovascular system
2 C09 Agents acting on the renin-angiotensin system
3 C09X Other agents acting on the renin-angiotensin system
4 C09XX Other agents acting on the renin-angiotensin system

Group C09XX contents

Code Title
C09XX01

Active ingredients in C09XX

Active Ingredient

Sparsentan is a dual endothelin angiotensin receptor antagonist. It is a single molecule that functions as a high affinity, dual-acting antagonist of both the ETAR and AT1R. Endothelin 1, via ETAR, and angiotensin II, via AT1R, mediate processes that lead to IgAN progression through haemodynamic actions and mesangial cell proliferation, increased expression and activity of proinflammatory and profibrotic mediators, podocyte injury, and oxidative stress. Sparsentan inhibits activation of both ETAR and AT1R and thereby reduces proteinuria and slows the progression of kidney disease.

Related product monographs

Document Type Information Source  
 FILSPARI Film-coated tablet MPI, US: SPL/PLR FDA, National Drug Code (US)
 FILSPARI Film-coated tablet MPI, EU: SmPC European Medicines Agency (EU)
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