ATC Group: D10AX Other anti-acne preparations for topical use

Aluminium chloride hexahydrate acts locally, in the stratum comeum and in the terminal duct, to relieve hyperhidrosis. It is is acidic and is thought to act by diffusing into the sweat ducts where on neutralisation it forms gelatinous hydroxides which obstruct the flow of sweat.

Azelaic Acid is a naturally occurring dicarboxylic acid. Azelaic acid possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity. Azelaic acid is bactericidal against Proprionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular proteins.

Clascoterone is an androgen receptor inhibitor. In vitro studies showed that it potently antagonizes the effects of androgens in primary human sebocytes to reduce sebum production and accumulation and inflammatory mediators which are known drivers of the acne pathogenesis.