ATC Group: J01DF Monobactams

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of J01DF in the ATC hierarchy

Level Code Title
1 J Antiinfectives for systemic use
2 J01 Antibacterials for systemic use
3 J01D Other beta-lactam antibacterials
4 J01DF Monobactams

Group J01DF contents

Code Title
J01DF01 Aztreonam
J01DF02 Carumonam

Active ingredients in J01DF

Active Ingredient Description

Aztreonam exhibits activity in vitro against gram-negative aerobic pathogens, including P. aeruginosa. Aztreonam binds to penicillin-binding proteins of susceptible bacteria, which leads to inhibition of bacterial cell wall synthesis, followed by filamentation and cell lysis.

Aztreonam and Avibactam

Aztreonam inhibits bacterial peptidoglycan cell wall synthesis following binding to penicillin-binding proteins (PBPs), which leads to bacterial cell lysis and death. Avibactam is a non β-lactam, β-lactamase inhibitor that acts by forming a covalent adduct with the enzyme that is stable to hydrolysis. Avibactam inhibits both Ambler class A and class C β-lactamases and some class D enzymes, including extended-spectrum β-lactamases (ESBLs), Klebsiella pneumoniae carbapenemase (KPC) and OXA-48 carbapenemases, and AmpC enzymes.

Related product monographs

Title Information Source Document Type  
AZACTAM Powder for solution for injection or infusion Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
CAYSTON Powder and solvent for nebuliser solution European Medicines Agency (EU) MPI, EU: SmPC
EMBLAVEO Powder for solution for infusion European Medicines Agency (EU) MPI, EU: SmPC