ATC Group: L01AX Other alkylating agents

The World Health Organization's ATC classification organizes medical drugs based on therapeutic properties, chemical composition, and anatomy. It helps make essential medicines readily available globally and is widely used in the pharmaceutical industry.

Position of L01AX in the ATC hierarchy

Level Code Title
1 L Antineoplastic and immunomodulating agents
2 L01 Antineoplastic agents
3 L01A Alkylating agents
4 L01AX Other alkylating agents

Group L01AX contents

Code Title
L01AX01 Mitobronitol
L01AX02 Pipobroman
L01AX03 Temozolomide
L01AX04 Dacarbazine

Active ingredients in L01AX

Active Ingredient Description
Dacarbazine

Dacarbazine is a cytostatic agent. The antineoplastic effect is due to an inhibition of cell growth which is independent of the cell cycle and due to an inhibition of DNA synthesis.

Temozolomide

Temozolomide is a triazene, which undergoes rapid chemical conversion at physiologic pH to the active monomethyl triazenoimidazole carboxamide (MTIC). The cytotoxicity of MTIC is thought to be due primarily to alkylation at the O6 position of guanine with additional alkylation also occurring at the N7 position. Cytotoxic lesions that develop subsequently are thought to involve aberrant repair of the methyl adduct.

Related product monographs

Title Information Source Document Type  
DACARBAZINE Powder for solution for injection or infusion Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
TEMODAL Hard capsule European Medicines Agency (EU) MPI, EU: SmPC
TEMODAL Powder for solution for infusion European Medicines Agency (EU) MPI, EU: SmPC