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ATC Group: P02CA Benzimidazole derivatives

Anatomical Therapeutic Chemical Classification System

Translations

Language
Translation
  English
Benzimidazole derivatives

Hierarchical Position

Level
Code
Title
4
P02CA
Benzimidazole derivatives

Contents

Code
Title
P02CA01
P02CA02
P02CA03
P02CA04
P02CA05
P02CA06

Active Ingredients

Chemical substance
Description

Αlbendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules.

In vitro and in vivo work suggests that mebendazole blocks the uptake of glucose by adult and larval forms of helminths, in a selective and irreversible manner. Inhibition of glucose uptake appears to lead to endogenous depletion of glycogen stores within the helminth. Lack of glycogen leads to decreased formation of ATP and ultrastructural changes in the cells.

Monographs

Monograph
Type
Country
MPI, EU: SmPC
UK