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ATC Group: R03DA Xanthines

Anatomical Therapeutic Chemical Classification System

Hierarchical position

Level
Code
Title
1
R
Respiratory system
2
R03
Drugs for obstructive airway diseases
3
R03D
Other systemic drugs for obstructive airway diseases
4
R03DA
Xanthines

Contents

Code
Title
R03DA01
Diprophylline
R03DA02
Choline theophyllinate
R03DA03
Proxyphylline
R03DA04
Theophylline
R03DA05
Aminophylline
R03DA06
Etamiphylline
R03DA07
Theobromine
R03DA08
Bamifylline
R03DA09
Acefylline piperazine
R03DA10
Bufylline
R03DA11
Doxofylline
R03DA12
Mepyramine theophyllinacetate
R03DA20
Combinations of xanthines
R03DA51
Diprophylline, combinations
R03DA54
Theophylline, combinations excl. psycholeptics
R03DA55
Aminophylline, combinations
R03DA57
Theobromine, combinations
R03DA74
Theophylline, combinations with psycholeptics

Active ingredients

Active Ingredient
Description
Aminophylline

Aminophylline is a soluble derivative of theophylline and is given for its theophylline activity. Aminophylline relaxes smooth muscle and relieves bronchial spasm. It stimulates the myocardium and reduces venous pressure in congestive heart failure, leading to a marked increase in cardiac output.

Bufylline

Bufylline is a combination of theophylline and aminoisobutanol used as a bronchodilator. It also acts and may be used as a diuretic.

Choline theophyllinate

Choline theophyllinate is the choline salt of theophylline. It has a strong bronchodilator action, due to the relaxation of the smooth muscle fibers of the bronchi.

Diprophylline

Diprophylline is a xanthine derivative with pharmacologic actions similar to theophylline and other members of this class of drugs. Its primary action is that of bronchodilation, but it also exhibits peripheral vasodilatory and other smooth muscle relaxant activity to a lesser degree. The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of the bronchial smooth muscle. Diprophylline exerts its bronchodilatory effects directly and, unlike theophylline, is excreted unchanged by the kidneys without being metabolized by the liver. Because of this, dyphylline pharmacokinetics and plasma levels are not influenced by various factors that affect liver function and hepatic enzyme activity, such as smoking, age, congestive heart failure, or concomitant use of drugs which affect liver function.

Dimethylxanthine

Theophylline is a bronchodilator. In addition it affects the function of a number of cells involved in the inflammatory processes associated with asthma and chronic obstructive airways disease. Theophylline stimulates the myocardium and produces a diminution of venous pressure in congestive heart failure leading to marked increase in cardiac output.

Monographs

Monograph
Type
Country
AMINOPHYLLINE INJECTION BP Injection
MPI, EU: SmPC
UK
UNIPHYLLIN CONTINUS Prolonged release tablets
MPI, EU: SmPC
UK