This brand name is authorized in Italy
The drug ACESISTEM contains a combination of these active pharmaceutical ingredients (APIs):
UNII 9O25354EPJ - ENALAPRIL MALEATE
Enalapril is hydrolysed via hepatic CES 1 to the active metabolite enalaprilat, which acts as an ACE inhibitor. ACE is a peptidyl dipeptidase which catalyses the conversion of angiotensin I to the vasoconstrictor substance angiotensin II and hence inhibition of ACE results in decreased plasma angiotensin II. This also leads to increased plasma renin activity and decreased aldosterone secretion. The mechanism of action of enalapril is therefore primarily via the suppression of the RAAS. However, ACE is identical to kininase II, and so enalapril may also exert its effects by blocking the degradation of bradykinin, a potent vasodepressor peptide.
UNII 0J48LPH2TH - HYDROCHLOROTHIAZIDE
Hydrochlorothiazide is a diuretic with antihypertensive properties. It acts by inhibiting the renal tubular re-absorption of sodium and chloride ions, which are excreted with an accompanying volume of water. Potassium excretion is also promoted.
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
|Enalapril and diuretics
|C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09B ACE inhibitors, combinations → C09BA ACE inhibitors and diuretics
This drug has been assigned below unique identifiers within the countries it is being marketed:
|Agenzia del Farmaco
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