Chemical formula: C₇H₈ClN₃O₄S₂  Molecular mass: 297.739 g/mol  PubChem compound: 3639

Active ingredient description

Hydrochlorothiazide is a diuretic and an antihypertensive agent. It affects the distal renal tubular mechanism of electrolyte reabsorption and increases excretion of sodium and chloride in approximately equivalent amounts.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code
Group title
C Cardiovascular system → C03 Diuretics → C03A Low-ceiling diuretics, thiazides → C03AA Thiazides, plain
Discover more medicines within C03AA03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Information Source
Document Type
Health Products Regulatory Authority (ZA)
MPI, Generic

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 58-93-5
DrugBank Drug: DB00999
KEGG Drug: D00340
PubChem Compound: 3639
RxNorm Ingredient: 5487
SNOMED-CT Concept: 387525002
Hydrochlorothiazide (substance)
UNII Identifier: 0J48LPH2TH


Hydrochlorothiazide is an active ingredient of these brands:

United States (US)

Australia (AU)

Austria (AT)

Brazil (BR)

Canada (CA)

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Germany (DE)

Hong Kong (HK)

Ireland (IE)

Italy (IT)

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Nigeria (NG)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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