Enalapril Other names: Enalapril maleate

Chemical formula: C₂₀H₂₈N₂O₅  Molecular mass: 376.447 g/mol  PubChem compound: 5388962

Active ingredient description

Enalapril is hydrolysed via hepatic CES 1 to the active metabolite enalaprilat, which acts as an ACE inhibitor. ACE is a peptidyl dipeptidase which catalyses the conversion of angiotensin I to the vasoconstrictor substance angiotensin II and hence inhibition of ACE results in decreased plasma angiotensin II. This also leads to increased plasma renin activity and decreased aldosterone secretion. The mechanism of action of enalapril is therefore primarily via the suppression of the RAAS. However, ACE is identical to kininase II, and so enalapril may also exert its effects by blocking the degradation of bradykinin, a potent vasodepressor peptide.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C09AA02 Enalapril C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09A ACE inhibitors, plain → C09AA ACE inhibitors, plain
Discover more medicines within C09AA02

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
AQUMELDI Orodispersible tablet European Medicines Agency (EU) MPI, EU: SmPC
VASOTEC Tablet FDA, National Drug Code (US) MPI, US: SPL/Old
INNOVACE Tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 75847-73-3
CAS Substance: 76095-16-4
DrugBank Drug: DB00584
KEGG Drug: D07892
PubChem Compound: 5388962
RxNorm Ingredient: 3827
SNOMED-CT Concept: 372658000
Enalapril (substance)
SNOMED-CT Concept: 414092003
Product containing enalaprilat (medicinal product)
UNII Identifier: 69PN84IO1A
ENALAPRIL

Medicines

Enalapril is an active ingredient of these brands:

United States (US)

Albania (AL)

Australia (AU)

Austria (AT)

Brazil (BR)

Canada (CA)

Croatia (HR)

  • AQUMELDI as Enalapril maleate
  • ENAP as ENALAPRIL MALEATE

  • (combination) ENAP HL as ENALAPRIL MALEATE
  • (combination) ENAP-H as ENALAPRIL MALEATE
  • (combination) LERCANIL ACE as ENALAPRIL MALEATE

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Finland (FI)

France (FR)

Germany (DE)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Italy (IT)

  • AQUMELDI as Enalapril maleate
  • CONVERTEN as ENALAPRIL MALEATE
  • ENAPREN as ENALAPRIL MALEATE
  • NAPRILENE as ENALAPRIL MALEATE

  • (combination) ACESISTEM as ENALAPRIL MALEATE
  • (combination) ATOVER as ENALAPRIL MALEATE
  • (combination) CONDIUREN as ENALAPRIL MALEATE
  • (combination) CORIPREN as ENALAPRIL MALEATE
  • (combination) ELEKTRA as ENALAPRIL MALEATE
  • (combination) ENEFIN as ENALAPRIL MALEATE
  • (combination) GENTIPRESS as Enalapril maleate
  • (combination) LANETIK as Enalapril maleate
  • (combination) LERCAPREL as ENALAPRIL MALEATE
  • (combination) SINERTEC as ENALAPRIL MALEATE
  • (combination) VASORETIC as ENALAPRIL MALEATE
  • (combination) ZANIPRIL as ENALAPRIL MALEATE

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Nigeria (NG)

  • ENVAS as ENALAPRIL MALEATE

  • (combination) ENARETIC as ENALAPRIL MALEATE

Poland (PL)

  • BENALAPRIL as ENALAPRIL MALEATE
  • ENAP as ENALAPRIL MALEATE
  • ENARENAL as ENALAPRIL MALEATE

  • (combination) CORIPREN as ENALAPRIL MALEATE
  • (combination) ELERNAP as ENALAPRIL MALEATE
  • (combination) ENAP HL as ENALAPRIL MALEATE
  • (combination) ENAP-H as ENALAPRIL MALEATE
  • (combination) LERCAPREL as ENALAPRIL MALEATE

Romania (RO)

  • ENAP as ENALAPRIL MALEATE
  • RENITEC as ENALAPRIL MALEATE

  • (combination) CORIPREN as ENALAPRIL MALEATE
  • (combination) ENAP HL as ENALAPRIL MALEATE
  • (combination) ENAP-H as ENALAPRIL MALEATE
  • (combination) ENEAS as ENALAPRIL MALEATE
  • (combination) LERCARIL as ENALAPRIL MALEATE

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

  • ANGIOTEC as ENALAPRIL MALEATE
  • ENAPRIL as ENALAPRIL MALEATE

  • (combination) ANGIOZIDE as ENALAPRIL MALEATE
  • (combination) HYPRIL as ENALAPRIL MALEATE
  • (combination) ZANEXTRA as ENALAPRIL MALEATE

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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