This brand name is authorized in Austria, Australia, Brazil, Canada, Cyprus, Ecuador, Estonia, Spain, Finland, France, Hong Kong, Croatia, Ireland, Israel, Italy, Lithuania, Mexico, Nigeria, Netherlands, Poland, Romania, Singapore, Turkey, United Kingdom, United States
The drug SIMBRINZA contains a combination of these active pharmaceutical ingredients (APIs):
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1
Brinzolamide
UNII 9451Z89515 - BRINZOLAMIDE
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Brinzolamide is an inhibitor of carbonic anhydrase II (CA-II). Carbonic anhydrase (CA) is an enzyme found in many tissues of the body, including the eye. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humour secretion resulting in a reduction in intraocular pressure (IOP) which is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss. |
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2
Brimonidine
UNII 4S9CL2DY2H - BRIMONIDINE TARTRATE
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Brimonidine is an alpha2-adrenergic receptor agonist that is 1000-fold more selective for the alpha2-adrenoceptor than the alpha1-adrenoreceptor. This selectivity results in no mydriasis and the absence of vasoconstriction in microvessels associated with human retinal xenografts. |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| SIMBRINZA Eye drops, suspension (eye drops) | European Medicines Agency (EU) | MPI, EU: SmPC |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| S01EC54 | S Sensory organs → S01 Ophthalmologicals → S01E Antiglaucoma preparations and miotics → S01EC Carbonic anhydrase inhibitors | |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: AU | Pharmaceutical Benefits Scheme | Identifier(s): 10536M, 10547D |
| Country: BR | Câmara de Regulação do Mercado de Medicamentos | Identifier(s): 526517050089107, 526517050089207 |
| Country: CA | Health Products and Food Branch | Identifier(s): 02435411 |
| Country: EC | Agencia Nacional de Regulación, Control y Vigilancia Sanitaria | Identifier(s): 1345-MEE-0915 |
| Country: EE | Ravimiamet | Identifier(s): 1657694, 1657706 |
| Country: ES | Centro de información online de medicamentos de la AEMPS | Identifier(s): 114933001 |
| Country: FI | Lääkealan turvallisuus- ja kehittämiskeskus | Identifier(s): 387012, 472984 |
| Country: FR | Base de données publique des médicaments | Identifier(s): 64880296 |
| Country: GB | Medicines & Healthcare Products Regulatory Agency | Identifier(s): 249969 |
| Country: HK | Department of Health Drug Office | Identifier(s): 64944 |
| Country: IE | Health Products Regulatory Authority | Identifier(s): 50805 |
| Country: IL | מִשְׂרַד הַבְּרִיאוּת | Identifier(s): 7977 |
| Country: IT | Agenzia del Farmaco | Identifier(s): 043532011, 043532023 |
| Country: LT | Valstybinė vaistų kontrolės tarnyba | Identifier(s): 1073921, 1073922 |
| Country: MX | Comisión Federal para la Protección contra Riesgos Sanitarios | Identifier(s): 126M2017 |
| Country: NG | Registered Drug Product Database | Identifier(s): B4-9101 |
| Country: NL | Z-Index G-Standaard, PRK | Identifier(s): 120197 |
| Country: PL | Rejestru Produktów Leczniczych | Identifier(s): 100317780 |
| Country: RO | Agenția Națională a Medicamentului și a Dispozitivelor Medicale | Identifier(s): W64462001 |
| Country: SG | Health Sciences Authority | Identifier(s): 15085P |
| Country: TR | İlaç ve Tıbbi Cihaz Kurumu | Identifier(s): 8699504710175 |
| Country: US | FDA, National Drug Code | Identifier(s): 0065-4147, 0078-0904 |
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