Brinzolamide
Chemical formula: C₁₂H₂₁N₃O₅S₃ Molecular mass: 383.507 g/mol PubChem compound: 68844
Active ingredient description
Brinzolamide is an inhibitor of carbonic anhydrase II (CA-II). Carbonic anhydrase (CA) is an enzyme found in many tissues of the body, including the eye. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humour secretion resulting in a reduction in intraocular pressure (IOP) which is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss.
Medicine classification
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC Group | Classification | |
|---|---|---|
| S01EC04 | Brinzolamide | S Sensory organs → S01 Ophthalmologicals → S01E Antiglaucoma preparations and miotics → S01EC Carbonic anhydrase inhibitors |
Product monographs
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Document | Type | Information Source | |
|---|---|---|---|
| AZOPT Eye drops, suspension | MPI, EU: SmPC | European Medicines Agency (EU) |
Structural formula
External identifiers
Medicines
Brinzolamide is an active ingredient of these brands:
Albania (AL)Australia (AU)
Austria (AT)Brazil (BR)Canada (CA)Croatia (HR)Cyprus (CY)Ecuador (EC)
Estonia (EE)Finland (FI)France (FR)Germany (DE)Hong Kong (HK)Ireland (IE)Israel (IL)Italy (IT)
Japan (JP)Lithuania (LT)Mexico (MX)Netherlands (NL)New Zealand (NZ)Nigeria (NG)Poland (PL)Romania (RO)Singapore (SG)South Africa (ZA)Spain (ES)Tunisia (TN)Turkey (TR)United Kingdom (UK)United States (US)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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