Brinzolamide

Chemical formula: C₁₂H₂₁N₃O₅S₃  Molecular mass: 383.507 g/mol  PubChem compound: 68844

Therapeutic indications

Brinzolamide is indicated for:

Elevated intraocular pressure, ocular hypertension, open-angle glaucoma

Population group: only adults (18 years old or older)

Brinzolamide is indicated to decrease elevated intraocular pressure in ocular hypertension or open-angle glaucoma as monotherapy in adult patients unresponsive to beta-blockers or in adult patients in whom beta-blockers are contraindicated, or as adjunctive therapy to beta-blockers or prostaglandin analogues.

For this indication, competent medicine agencies globally authorize below treatments (click for details):

Contraindications

Brinzolamide is contraindicated in the following cases:

Hypersensitivity to sulphonamides

Allergy to sulfonamides

Severe renal impairment

at least one of

Renal failure stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis)

Hyperchloraemic acidosis

Metabolic acidosis, NAG, acidifying salts

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