ICD-10 Specific code C72.8: Malignant neoplasm: Overlapping lesion of brain and other parts of central nervous system

Specific codes in ICD-10 are unique alphanumeric designations used to identify and categorize diseases, disorders, and conditions. They consist of 3-5 characters, including both letters and numbers, that provide a high level of detail and specificity.

Translations

Language Translation
Flag for English language  English Malignant neoplasm: Overlapping lesion of brain and other parts of central nervous system
Flag for French language  French Tumeur maligne ร  localisations contiguรซs de l'encรฉphale et d'autres parties du systรจme nerveux central

Hierarchical position

Level Code Title
1 II Neoplasms
2 C00-C97 Malignant neoplasms
3 C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
4 C72 Malignant neoplasm of spinal cord, cranial nerves and other parts of central nervous system
5 C72.8 Malignant neoplasm: Overlapping lesion of brain and other parts of central nervous system

Indicated medicines

Active Ingredient Description
Ifosfamide

Ifosfamide is an antineoplastic, a cytotoxic alkylating agent. It is a prodrug and shows no in vitro cytotoxic activity until activated by microsomal enzymes. The cytotoxic activity of ifosfamide (alkylation of the nucleophilic centres in the cells) is associated with the activated oxazaphosphorine ring hydroxylated at the C4 atom which interacts with DNA-DNA cross linking. This activity manifests itself by blocking the late S and early G2 phases of the cell cycle.

Thiotepa

Thiotepa is a polyfunctional cytotoxic agent related chemically and pharmacologically to the nitrogen mustard. The radiomimetic action of thiotepa is believed to occur through the release of ethylene imine radicals that, as in the case of irradiation therapy, disrupt the bonds of DNA, e.g. by alkylation of guanine at the N-7, breaking the linkage between the purine base and the sugar and liberating alkylated guanine.