ICD-10 Specific code D47.4: Osteomyelofibrosis

Specific codes in ICD-10 are unique alphanumeric designations used to identify and categorize diseases, disorders, and conditions. They consist of 3-5 characters, including both letters and numbers, that provide a high level of detail and specificity.

Translations

Language Translation
Flag for English language  English Osteomyelofibrosis

Hierarchical position

Level Code Title
1 II Neoplasms
2 D37-D48 Neoplasms of uncertain or unknown behaviour
3 D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
4 D47.4 Osteomyelofibrosis

Also includes

Chronic idiopathic myelofibrosis
Myelofibrosis (idiopathic) (with myeloid metaplasia)
Myelosclerosis (megakaryocytic) with myeloid metaplasia
Secondary myelofibrosis in myeloproliferative disease

Does not include

Acute myelofibrosis (C94.4)

Indicated medicines

Active Ingredient Description
Busulfan

Busulfan is a potent cytotoxic agent and a bifunctional alkylating agent. In aqueous media, release of the methanesulphonate groups produces carbonium ions which can alkylate DNA, thought to be an important biological mechanism for its cytotoxic effect.

Ifosfamide

Ifosfamide is an antineoplastic, a cytotoxic alkylating agent. It is a prodrug and shows no in vitro cytotoxic activity until activated by microsomal enzymes. The cytotoxic activity of ifosfamide (alkylation of the nucleophilic centres in the cells) is associated with the activated oxazaphosphorine ring hydroxylated at the C4 atom which interacts with DNA-DNA cross linking. This activity manifests itself by blocking the late S and early G2 phases of the cell cycle.