Active Ingredient: Metoprolol
For this indication, competent medicine agencies globally authorize below treatments:
Oral
50 - 200 mg
From 12.5 To 50 mg 4 time(s) per day every day
50 mg
Early intervention: Orally, therapy should commence 15 minutes after the last intravenous injection with 50mg every 6 hours for 48 hours and preferably within 12 hours of the onset of chest pain. Patients who fail to tolerate the full i.v. dose should be given half the suggested oral dose.
Maintenance: The usual maintenance dose is 200 mg daily given in divided doses. The treatment should be continued for at least 3 months.
Intravenous
5 - 15 mg
From 5 To 15 mg once every day
Intravenous metoprolol should be initiated in a coronary care or similar unit when the patient’s haemodynamic condition has stabilised. Therapy should commence with 5 mg I.V. every 2 minutes to a maximum of 15 mg total as determined by blood pressure and heart rate. The second or third dose should not be given if the systolic blood pressure is <90 mmHg, the heart rate is <40 beats/min and the P-Q time is >0.26 seconds, or if there is any aggravation of dyspnoea or cold sweating. Oral therapy should commence 15 minutes after the last injection with 50 mg every 6 hours for 48 hours. Patients who fail to tolerate the full intravenous dose should be given half the suggested oral dose.
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